产物官能团类型
1. SOCl2
二氯亚砜（SOCl2）通常用于将羧酸转化为酸氯。通常的条件是将底物在纯SOCl2中回流搅拌数小时。有时会使用溶剂（例如ACN）。
案例
A mixture of the SM (1.0 g, 6.3 mmol) in ACN (20 mL) was treated with SOCl2 (0.8 mL). The resulting mixture was refluxed for 2 h. The solvent was removed in vacuo to provide the crude product as an oil which was used in the next step without further purification.
Patent Reference: WO2010016005, page 89
2. (COCl)2
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草酰氯 [(COCl)2] 也常用于将羧酸转化为酸氯。该过程通常是在室温下将底物与 (COCl)2 和催化量的 DMF 在 DCM 中搅拌完成。
案例
TTo a suspension of the SM (0.3 g, 2.38 mmol) in DCM (10 mL) was added (COCl)2 (0.3 mL, 3.6 mmol) dropwise at 0 C. The resulting mixture was stirred at RT for 1 h then heated to 70 C for 2 h. After cooling to RT the excess (COCl)2 and solvent were removed in vacuo (at <40 C) to provide the product as a gum which was taken to the next step without further purification.
Patent Reference: WO2010038081, page 138
反应机理
