硼氢化钠对醛的还原是一类及其常见,极其常用的还原反应。反应条件往往为0 °C或室温,反应溶剂常优选MeOH,其他的如THF,EtOH
The SM (785 mg, 2.71 mmol) was dissolved in THF (5.0 mL) and MeOH (5.0 mL). The mixture was cooled to 0 C and treated with NaBH4 (156 mg, 4.07 mmol). The reaction mixture was stirred at RT for 30 min. Excess reagents were consumed by the addition of aq NH4Cl and the mixture was stirred at RT for 10 min. The mixture was extracted with EtOAc. The org layer was washed with aq NH4Cl, brine, dried (MgSO4), and concentrated. The resulting material was purified by silica gel flash chromatography to provide the product as a white solid. [626 mg, 79%]
Patent Reference: WO2016014463, page 99