产物官能团类型
Pinner反应
Pinner反应可用于将腈转化为酯。多种类型的腈可以作为底物（例如，脂肪族、芳香族和杂芳香族腈）。最常用的醇是甲醇（MeOH）和乙醇（EtOH），但许多一元醇和二元醇也被用于该反应。
案例
注意，在该反应中对酸敏感的Boc,TES也一同被脱除。也就是说，酸敏感的底物要提前考虑其反应特性。
To a solution of the SM (0.2 g, 0.3 mmol) in EtOH (5 mL) was added conc. HCl (5 mL). The reaction mixture was stirred at reflux overnight. The mixture was quenched with H2O (50 mL), basified with 10% NaOH up to pH 9, and extracted with EtOAc (2 x 30 mL) The combined organics were washed with H2O (50 mL), brine (50 mL), dried (Na2SO4), and concentrated. The resulting material was purified by silica gel column chromatography (30% EtOAc/hexane) to provide the product as a white solid. [0.1 g, 92%]
Patent Reference: WO2015129926, page 83